In 1866, due to expansion in Bridgetown (now South Perkasie), Rev. Peter S. Fisher of Tohickon Reformed (Weisel, PA) and Rev. Fred Berkemeyer of St. Peter's Lutheran (Fricks, PA) helped create St. Andrew's Union Church. Rev. Fisher became the first pastor, and served until 1873. A building site was chosen at 5th and Walnut Streets, but when the Sellersville group decided to build their own church, it was changed to 615 E. Walnut Street.

The cornerstone was laid June 10th, 1867, but the deed was dated June 28. The property had sheds in back for horses and buggies and a small burial area, which was first used that same year. The cost of the building was $2,500.00 and was shared by the members and local Mennonites, who contributed liberally. It was named in honor of the Reverend J. Andrew Strassburger, a highly esteemed pastor of three local congregations and who was the original owner of the property, which was sold to the church by his son-in-law.

The charter was granted on February 12, 1869. In 1882 an organ was purchased and the church interior was renovated. The bell tower, bell, and front stairway were installed in 1890. In 1908 the interior was repainted and new pews, altar, and pulpit furniture, carpet, and steam heating system were installed. In 1911 a new pipe organ was installed, with each congregation paying $500.00, and Andrew Carnegie donating $750.00. Charles J. Fehl donated the organ chimes in 1948.

The Lutheran congregation left in 1956 and the Reformed congregation purchased their interest in the property, but they continue to cooperate with the Union Cemetery and cemetery board.

In 1971 the church erected a fellowship hall with a kitchen on the upper level and Sunday School rooms on the lower level.